A novel role of TCF family in body axis formation Revolutionary high impact discoveries are described, elucidating the missing link in the Wnt pathway and protein-TCF combinations with dual functions By studying the primary axis formation of Xenopus laevis, it was firstly shown that, in combination with beta-catenin, TCF acts as a potent activator ожужу of proto-oncogenes Secondly, it was discovered that in combination with the Groucho family of proteins, TCF acts as suppressor of oncogene transcription Stronlgy suggesting that TCF controls oncogene transcription in a dual fashion These discoveries contributed to the origination of a major area of cancer research and opened multiple angles for cancer therapy development. В том вошел2010 г Мягкая обложка, 80 стр ISBN 3838320522. |